Treating Chronic Pain with Psilocybin

Chronic pain is often "learned" by the brain, persisting long after a physical injury has healed. Psilocybin is showing promise in "resetting" these pain pathways, offering relief for conditions like fibromyalgia, phantom limb pain, and complex regional pain syndrome (CRPS).

A 2025 study by Penn Medicine revealed that psilocybin modulates specific brain circuits that process both pain and emotion.

• The Brain Connection: Chronic pain and depression often share the same neural circuitry. Psilocybin appears to desensitise these overactive pain networks while simultaneously boosting mood.

• Neuroplasticity: By promoting the growth of new neural connections, psilocybin may help the brain "unlearn" the signal of chronic pain, offering a potential alternative to addictive opioids.