Using psilocybin for Longevity & Anti-Aging

Can Psilocybin Increase Life Span?

Beyond mental health, groundbreaking new research suggests psilocybin may have profound effects on physical aging. Recent studies indicate that the compound may reduce cellular stress and inflammation, potentially slowing the biological aging process and extending the healthy lifespan.

Research published in 2025 by Emory University has provided some of the first biological evidence linking psilocybin to longevity. The study found that psilocin (the active metabolite of psilocybin) extended the lifespan of mice and reduced oxidative stress at a cellular level.

• Key Finding: The study observed that mice treated with low doses of psilocybin showed improved stress resilience and reduced markers of age-related inflammation (inflammaging).

• Why it matters: This suggests psilocybin promotes homeostasis—the body's ability to maintain stability—which degrades as we age.

• While human trials are needed, this points to a future where psilocybin could be used not just for the mind, but as a "geroprotector" for the body.